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In Glp1r VSM+/+ mice, semaglutide induced modest but detectable proteomic shifts, with downregulation of 5 proteins enriched in pathways linked to apoptotic signaling, including caspase activation, second mitochondria-derived activator of caspasesdependent pathways and general regulators of programmed cell death

Research has investigated its effects on metabolic markers including HbA1c, fasting glucose, lipid profiles, and hepatic lipid content in preclinical and clinical models

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It belongs to a class of drugs known as GLP-1 receptor agonists